As the equipment is not easily portable, samples can be compromised during travel. A low response time allows one to quicky execute operations such as stop flow and pressure/flow rate steps. The MFCS series products are well adapted to the manipulation of fluid volumes in the low to sub microliter per minute range. It can support a wide range of connections (Wi-Fi, BLE, IoT, USB, industrial bus), and embedded protocols. The technology used in this pressure pumpavoids cross contaminationbecause liquids only contact air. In the base configuration, the system controls pressure or vacuum, and the liquid flow is a function of system resistance, fluid viscosity, etc. Fig 1: (left) A pressure supply and pressure controller vs our new technology (right) Fluigent engineered technology. Fluigent is an international company which develops, manufactures and supports the most advanced fluid control systems available for microfluidics offering greater control, automation, precision, and ease of use.. Using a pressure leakage or a valve in complement to the pump is a way to circumvent this limitation. How to set the Flow EZ (power and pressure supply), Fluidic and pneumatic connection to the microfluidic setup, Extend the pressure system by adding modules, How to send and apply an order to pressurize a reservoir, How to disconnect a module to modify the pressure system, Add a flow sensor to control directly in flow rate, Switch the module OFF and stop the experiment, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, 0,1% on the measured value (effective beyond 10% of the maximum pressure), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, Things you should know when integrating fluidics into your system, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, Droplet generation using syringe pumps and pressure-based flow controllers, Extended capabilities of pressure driven flow for microfluidics applications, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, Pressure predictions for lab-on-a-chip operations using a microfluidic network solver and Fluigent PX, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Control in real-time, protocol automation, data record and export. A switch module is also directly connected to the F-OEM main board, allowing for connecting a bidirectional 11-port / 10-way microfluidic valve for injection or selection of up to 10 different fluids (Fluigent M-X). The MFCS-EX provides up to 8 negative or positive pressure channels to pressurize multiple fluid reservoirs. Either 4 or 8 channels are available with different pressure ranges for microfluidic experiments. Mixed pressure ranges can be connected to the same board (positive and negative pressures, and Push-Pull). The PX Pressure-driven flow control simplifies fluid management even for multiple fluids, and reduces the time needed to add or remove channels. The technology consists of a uniquely engineered assembly of electronics, sensors integrated with a micropump, and pneumatics to provide high performance. The MFCS series product range is the first generation of microfluidic systems. The PX module is a CE and RoHS compliant single controller available in 3 pressure ranges. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. Valve and switch platform for directing the fluid flow, including bidirectional and rotary multi-port port valves. Configuration 2: 2 pressure modules 2 flow sensors. TheLineUpPush-Pullis a standalone controller with the ability to deliverfinely regulated pressureor avacuumthrough a single outlet over the range of-800 to +1000 mbar. Each module is a separate and independent pressure channel. Fluigent developed the patented FASTAB technology: a pressure-driven technology that has no moving parts and includes an advanced feedback control algorithm to maintain precise pressure control. When combined with theLINKmodule, the Flow EZcapabilities are extended by using Fluigent software to control the system, or to generate time based protocols and reccord data(OxyGEN software). 0.1% thanks to our field-proven, patented FASTAB technology allowing optimal flow control with the robustness required in demanding industrial environments. For flow-rate monitoring and control. Benefit from the best performance and Fluigent expertise for your project. The MFCS is a pressure based microfluidic flow controller. 2. Our innovative pressure-based microfluidic controllers are compatible with lab on a chip device and a wide variety of microfluidic technologies that will allow you to focus on the science, not on the setup.
How to set the Flow EZ (power and pressure supply), Fluidic and pneumatic connection to the microfluidic setup, Extend the pressure system by adding modules, How to send and apply an order to pressurize a reservoir, How to disconnect a module to modify the pressure system, Add a flow sensor to control directly in flow rate, Switch the module OFF and stop the experiment, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, A human BBB (blood brain barrier)-on-chip to assess vascular permeability, Doing PhD with Fluigent 2021: Research on Honey by Daniel Kraus (Jena, Germany), Hans-Knll-Institut, New Antibiotics, Cultivation in Droplets, Microfluidic white paper An exploration of Microfluidics and fluid handling, LineUp Series, the new generation of microfluidic controllers, The Hebrew University: Single-cell encapsulation and culture in 3D hydrogels followed by InDrops / Drop-Seq microfluidic protocols for RNA profiling, University of Cambridge: Giant unilamellar vesicle production and testing, The Micro/Nano Bioelectronics and Biosensors (MBIOS) from Tianjin University, Peristaltic pump vs pressure-based microfluidic flow control systems for Organ on-chip applications, E. Coli culture in droplets using dSURF fluorosurfactant, Characterization of copper electrodeposition in liquid phase electron microscopy, Production of water-in-oil emulsions using a droplet generator chip, Droplet generation using syringe pumps and pressure-based flow controllers, Comparison between peristaltic, syringe and pressure pumps for microfluidic applications, University of Maryland: A soft robotic hand with integrated fluidic circuitry that can play Nintendo, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, 0,1% on the measured value (effective beyond 10% of the maximum pressure), Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export. The PRESSURE UNIT product line allow for the accurate measurement of pressure and vaccum within the range -1000 mbar to 7 bar. This allows the user to set a flow rate directly on the instrument display. With the Flow EZ or Push-Pull modules one can precisely regulate and control pressure & vacuum, the LINK and LINK COM modules provide communication to a computer or any external instrument using TTL ports, USB cable or Serial port communication.
In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. Our F-OEM offers our highest performance, efficiency, and widest pressure and flow rate ranges to support the most demanding industrial applications, including microfluidic and nanofluidic applications (microchannels, nanochannels, capillaries, lab on a chip). The product line can detect values over the range of-1000 mbar(-15 psi) to7000 mbar(100 psi). Pulse-free flow is critical for generating high quality and repeatable results. Fig 2: (left) Pneumatic schematic of a standard fluidic system using pressure to move fluids (right) Pneumatic schematic of Fluigent new technology. Pulse-free flow is critical for generating high quality and repeatable results. Flow sensors are connected for flow rate monitoring and control. Liquid flow rate ranges from a few nL/min to 5 mL/min. 8, 114 (2021). If you are seeking to replace high-precision syringe pumps or other conventional instruments, we offer modern microfluidic systems and components that enhance productivity.. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. Connect the outlets of the P-SWITCH to independent reservoirs to perform independent injections. The Push-Pull allows for regulatation of pressure and vacuum down to -800 mbar and up to 1 bar from one single channel. These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. You can choose the number of channels of the device (4 or 8), each channel range from -800 mbar to 7 bar, and you even have the possibility to integrate a pressure or vacuum source inside the instrument. The platform allows one to choose the number of pressure modules (with different ranges, if required), valve modules, and flow sensors. The technology is powered by an embedded rechargeable battery to facilitate portability. Each module is a separate and independant pressure channel. Janire, S., Raquel, C.-C., R_oisn, M. O. Fluigents unique broad range of solutions for use in microfluidic and nanofluidics applications ensure full control of flow rates with a greater control, automation, precision, ease of use and also minimize contamination.
The flow generated can be measured or controlled with FLOW UNITs and the Flowboard. The F-OEM makes use of Fluigents patented Fastab 2 technology. In the base configuration, the system controls pressure, and the liquid flow is a function of system resistance, fluid viscosity, etc.
Due to its individually stackable channels adapted for different pressures, the PX series allowed for control of the different pressure variations required. The pulseless and precise control enabled by our pressure-driven technology is critical for repeatable results in many applications. In this stand-alone configuration, the device allows for pressure or flow rate control and volume dispense making it ideal for benchtop use. There are many advantages to direct control: Configuration 1: 2 pressure modules. Combined with a FLOW UNIT it allows for direct control of flow rate. The addition of aFLOW UNITenables one tocontrol or monitor flow rateas well asmeasure a dispensed volume. Single gateway for industrial-grade microfluidic control: The platform can be used to control a pressure source and power other third-party devices required in the microfluidic system. With the addition of a pressure leakage component, the pressure drop now takes about 5 seconds (see Fig. It provides a dual interface USB and RS232 for high versatility in the integration. Range available from -800 mbar for vacuum aspiration and up to 7 bar for pressure. Fluigent pressure and flow controllers bring this performance and benefits to the system. By using the FASTAB microfluidic patented technology, the MFCS generates a constant pressure-driven flow rate that allows for reliable and repeatable experiments. These can easily be combined tomatch all application requirementsor reconfigure the system for a new experimental design. Point of care tests such as blood analysis, glucose monitoring, infectious disease testing, cholesterol testing, or cardiac markers are marketed1. The device is well designed and allows for easy control of my microfluidic chips. Each channel can be controlled independently and deliver a specific amount of pressure or vacuum to handle fluids. Fluigent has delivered thousands of patented pressure-flow controllers systems to hundreds of customers worldwide. is well-suited technology for applications that require mobile or compact fluidic control devices, including point of care (PoC) diagnostic and testing, or for water and soil on-site analysis.
Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. Migrating cells in dynamic chemical gradients generated by a microfluidic chamber (cells, gray; chemoattractant with fluorescein,green). Pressurize up to 32 reservoirs simultaneously or independently. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics. It provides flexibility without compromising performance (accuracy and response time).
This system can be integrated, automated or control in real time by using Fluigent Software Solutions. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand. The Flow EZ integrates the all-new DFC (Direct Flow Control) algorithm. The benefits of this technology are listed below. The algorithm includes a continuous optimization of the parameters that allow it to adapt to the interactions between microfluidic channels in complex situations. The P-SWITCH allows to multiply the outlets of the system and the SWITCH EZ controls microfluidic valves. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Explore our 15 years of field-proven experience, Developing a new fluidic system? Control without a PC using the Push-Pull hardware interface with one hand.
Bioeng. Fluigents broad range of solutions for use in microfluidic and nanofluidic applications offer greater control, automation, precision, and ease of use.
As an alternative, microfluidic-based portable devices have been developed for on-site analysis. Our technology is an excellent fit for such applications as it is fully connected and provides excellent fluidic performance while being compact. The Push-Pull integrates the all-new DFC (Direct Flow Control) algorithm. The field-proven technology ensures to obtain quickly reliable and superior results for your experiments. The use of pressure to handle fluids also provides a quick response time allowing for precise operations such as stop flow and accurate pressure/flow rate steps. Combine it with a flow sensor to regulate directly in flow rate and inject precise amounts of volume in the system. The FLUIGENT PX pressure controller is a single, miniaturized electronic pressure controller with an integrated and intelligent feedback loop for highest performance. Continuous monitoring of water resources such as freshwater, seawater, and, in particular, wastewater and drinking water, for human and animal consumption, is essential2. Each P-SWITCH module requires 2 supplied sources overthe range or -800 mbar to 2 bar. Front. One can use large reservoirs and maintain continuous, pulseless flow for days without refilling. We provide instrument development industrial engineers with the right liquid handling solution for your system.
The applied pressure will automatically adjust to maintain the flow rate.
We offer modern microfluidic systems and components that enhance productivity. Based on the patented FASTABTM technology, our pressure and flow controllers ensure a stable and pulseless flow to enhance accuracy and reproducibility in the experiments. Based on our industry leading experience, Fluigent has developed the patented QuadCore pneumatic system, the most advanced microfluidic pumping technology available. Instead of looking at the PC, users can keep their eyes on the microscope, adjusting the control dial with one hand.
The entire system can be controlled without a PC using local control and can also be monitored by Fluigent Software to extend its capabilities and benefit from automation. Combine up to 12 modules as your work flow grows. Expand your system up to 32 outlets with 4 modules. Fluigents i (patent pending) powerful pressure regulation algorithm is based on physical equations and self-learning routines that offer several benefits: By directly connecting a flow rate sensor, it is possible to monitor or control flow rate in real time. It is at the heart of the Fluigents next generation performance providing the fastest, most stable and compact system for microfluidics available. The Flow EZ can maintain continuous, pulseless flow for days without refilling.
Select modules you need and combine them together. This allows to perform operations that require fast response time, or require fast change between applied positive pressure and vacuum. Combine as many modules as you want to fit your application needs. Whether your application is with droplets, cell biology, particle studies, or in other research areas, we have the expertise and knowledge to provide the most cost-effective and technically advanced solutions for your fluid control needs. Custom software application: Public SDK libraries are available on GitHub for all integration into the users proprietary software, Adapted to cell culture or other experiments involving resistance variations: the algorithm adjusts its model to the setup resistance in real-time, Save precious sample or reagent: reduced time to reach desired flow rates uses less liquid during a calibration step, Save time with reduced settling time and no calibration. It can be used without a PC or controlled with Fluigent Software Solutions to benefit from control in real-time, protocol automation, graphic displays and custom integration. These can easily be joined together tomatch all application requirementsor reconfigure the system for a new experimental design. For more information or a technical discussion, 67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics.
Connecting the pressure outputs to airtight reservoirs provides precise and smooth control of the sample flow into the microfluidic device. Control without a PC using the Flow EZ hardware interface with one hand. When combined with a FLOW UNIT, one can control flow rate directly or deliver dispensed volumes as needed. When using a gas micropump alone, pressure drops are very slow, as shown in Fig. The technology used in this pressure pumpavoids cross-contaminationbecause liquids only contact air.
Our engineered systems tackle these limitations by bringing a cost-effective solution with a highly reduced footprint. We have a large range of flow sensors ranging from 0-1.5 L/min to 0-5 mL/min. The MFCSTM series and Flow EZTM with Fluigent valves can be used for automated cell perfusion as in the next video.
67 avenue de Fontainebleau94 270 Le Kremlin-Bictre, LineUp Series, the new generation of microfluidic controllers, All-in-one pressure supply & pressure/flow control, Advantages of pressure-based microfluidics, Droplet and particle generation in microfluidics, Dry, oil-free gas, air, any non corrosive or non explosive gas, Aqueous solvent, oil, organic solent, biological sample, Control in real-time, protocol automation, data record and export.
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